Complex pathologies in mother, child, and reproductive medicine

Tipologia: Malattie Infettive

Principal Investigator: Spinillo

The role and implication of minimally invasive technology and robotics in gynecological field for benign and malignant diseases;
The role of placental lesions in the obstetrics outcomes with particular attention to preterm newborn, the correlation between autoimmune disease in the pregnancy outcomes (collaboration with rheumatology and endocrinology);
New strategy for targeting medical treatment in gynecological malignancies;
Nanotechnology applied to endometriosis and gynecological field;
Immunology and immunophatology of HPV infection in the CIN development;
Investigation of genetics of gynecological cancers, especially endometrial and ovarian cancer;
Investigation on vertical infection and their role in maternal and fetal outcomes;
New techonologies and AI application in gynecology and obstetrics.

Gardella B., Dominoni M., Caporali C., Cesari S., Fiandrino G., Longo S., De Vito G.B., Naboni C., Tonduti D., Perotti G., Orcesi S., Spinillo A. Placental features of fetal vascular malperfusion and infant neurodevelopmental outcomes at 2 years of age in severe fetal growth restriction. American Journal of Obstetrics & Gynecology, 2021;
Revello M.G., Lazzarotto T., Guerra B., Spinillo A., Ferrazzi E., Kustermann A., Guaschino S., Vergani P., Todros T., Frusca T., Arossa A., Furione M., Rognoni V., Rizzo N., Gabrielli L., Klersy C., Gerna G., CHIP Study Group. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. The New England Journal of Medicine, 2014;
Gardella B, Dominoni M, Cassani C, Francesca Pasquali M, Spinillo A. Treatment of uncomplicated vulvovaginal candidiasis: topical or oral drugs? Single-day or multiple-day therapy? A network meta-analysis of randomized trials. Am J Obstet Gynecol. 2025 Sep;233(3):152-161. doi: 10.1016/j.ajog.2025.03.031. Epub 2025 Mar 27. PMID: 40157526.;
Cassani C, Dominoni M, Pasquali MF, Gardella B, Spinillo A. The role of multiple high-risk human papillomavirus infection on the persistence recurrence of high-grade cervical lesions after standard treatment: A systematic review and a meta-analysis. Acta Obstet Gynecol Scand. 2024 Jun;103(6):1028-1035. doi: 10.1111/aogs.14827. Epub 2024 Mar 13. PMID: 38477097; PMCID: PMC11103134.;
Spinillo A., Beneventi F., Caporali R., Ramoni V., Montecucco C. Undifferentiated connective tissue diseases and adverse pregnancy outcomes. An undervalued association? American Journal of Reproductive Immunology, 2017.

Endogold project
RC: HPV Immunological markers of cervical persistent infection and oncogenesis: HPVIMMUNO study
RC: Development and validation of artificial intelligence-based analysis software to support screening system of cervical intraepithelial neoplasia and colposcopic evaluation: HPVAI study

•    ULTRAMIS study group (international Collaboration with PI Prof. Ignacio Zapardiel, Madrid, Spain);

•    VULCAN study group (International Collaboration with PI Prof. Ignacio Zapardiel, Madrid, Spain);

•    SARCUT study (international Collaboration with PI Prof. Ignacio Zapardiel, Madrid, Spain);

•    Collaboration with Ospedale di Ancona, Prof. Andrea Ciavattini, Ancona, Italy, for HPV infection and low genital tract diseases;

•    Collaboration with dot. Alessandro Borghesi, OSM, and the laboratory of Zurigo, Switzerland for the research on GWAS in pregnancy and newborns;

•    Endogold (national collaboration with PI Prof. Simone Ferrero, Genova, Italy);

•    Collaboration with University of Naples, L. Vanvitelli per cardiotography evaluation during pregnancy (Dott. La Verde);

•    Collaboration with University of Pavia, department of Engineering for AI interpretation support of cardiotrography during pregnancy and labour (Prof. Magenes);

•    Collaboration with University of Pavia, department of Engineering for AI interpretation support of colposcopy and HPV cervical lesions (Prof. Parimbelli);

•    Collaboration with University of Pavia, department of publich health for nutrition role in endometriosis and cronic pelvic pain (Prof. Ferraris);

•    Collaboration with University of Turin, department of genetics (Prof. Proserpio) for the PRIN 2022 - 2022CLTAYH_002 about vulvodynia.