Gruppi di Ricerca

Cardiovascular Clinical Research Center CCRC - Gruppo di Ricerca

REFERENTE - GROUP LEADER

Prof. LEONARDI Sergio

CURRICULUM VITAE REFERENTE

CV Prof. Leonardi Sergio

SPECIFIC ROLE

Coordination of the Unit's research activities.

GROUP MEMBERS
Daniela Civardi, Alessia Currao, Monica Portolan, Giulia Spoto, Matteo Micale, Valentina Spirlì.

RESEARCH PROJECTS

The Cardiovascular Clinical Research Center (CCRC) is an independent clinical research program (Unità Operativa di Ricerca) that is involved in every aspect of cardiovascular clinical research at the Fondazione IRCCS Policlinico S. Matteo. Its focus is on the design and implementation of randomized clinical trials and observational studies across the whole spectrum of cardiovascular diseases.
An area of specific expertise and excellence is the conceptualization, design, and implementation of innovative quality improvement initiatives, such as the clinical governance programme of patients with acute coronary syndrome (ClinicalTrials.Gov ID NCT04255537), one of the largest conducted in Italy.

The CCRC personnel operates and coordinates site-based clinical research activities and work in close collaboration with the next generation of clinician investigators. The CCRC goal is to improve patients’ care by translating scientific evidence into clinical practice.
5 BEST PAPERS
- Leonardi S., Montalto C., Carrara G. et al. ACS Clinical Governance Programme Investigators. Clinical governance of patients with acute coronary syndromes. European Heart Journal Acute Cardiovascular Care, 2022;
- Leonardi S., Montalto C., Casella G. et al. Clinical governance programme in patients with acute coronary syndrome: design and methodology of a quality improvement initiative. Open Heart, 2020;
- Leonardi S., Gragnano F., Carrara G. et al. Prognostic Implications of Declining Hemoglobin Content in Patients Hospitalized With Acute Coronary Syndromes. Journal of the American College of Cardiology, 2021;
- Lopes R.D., Leonardi S., Wojdyla D.M. et al. Stent Thrombosis in Patients With Atrial Fibrillation Undergoing Coronary Stenting in the AUGUSTUS Trial. Circulation, 2020;
- Leonardi S., Branca M., Franzone A., et al. Comparison of Investigator-Reported and Clinical Event Committee-Adjudicated Outcome Events in GLASSY. About Circulation: Cardiovascular Quality and Outcomes, 2021.
AVAILABLE TECHNOLOGY

Personal computer, laptop and standard technology for clinical research.
RUNNING FUNDS

Externally sponsored research of AstraZeneca (ESR-16–12480) grant of 120.000 EU.
NATIONAL AND INTERNATIONAL STRATEGIC COLLABORATIONS
- Duke Clinical Research Institute, NC, USA;
- Università della Svizzera Italiana, Lugano;
- ATBV network (Gruppo di studio italiano su aterosclerosi, trombosi, e biologia vascolare).